Vercellini P, Oldani S, Felicetta I, Trespidi L, Bramante T, Crosignani PG
Clinica Osterica e Ginecologica "Luigi Mangiagalli" University of Milan, Via Commenda 12, 20122 Milan, Italy.
J Am Assoc Gynecol Laparosc. 1994 Aug;1(4, Part 2):S38. doi: 10.1016/s1074-3804(05)80992-2.
Serum and cystic fluid levels of CA 125, CA 19.9, carcinoembryonic antigen (CEA), and alpha-fetoprotein (AFP) were assayed in 74 consecutive women of median age 30 years (range 15 to 74 years) undergoing surgery for adnexal cysts of presumed benign nature. Median (range) serum levels of CA 125, CA 19.9, CEA and AFP were 46.5 IU/ml (4.3-406), 28.5 IU/ml (1-96.3), 1.4 ng/ml (0.5-3.5) and 2.4 ng/ml (1-9.9) in 44 endometriotic cysts; 22.5 (4.7-82), 4.9 (1-226),1.3 (0.7-4.8) and 4 (0.5-10.5) in 11 dermoid cysts, 14 (8.6-25.1), 3.2 (1-6), 1 (0.3-2.8) and 3.7 (1.9-6) in 9 mucinous cysts, and 6.9 (0.5-104), 18 (1-132), 0.8 (0.1-1.9) and 2.1(1-5.4) in 10 cases with mixed histotypes. Corresponding cystic fluid levels were 342,864 (1,418-3,404,682), 228,000 (117-2,500,000), 106 (0.5-2,908) and 1.3 (0.4-51) in endometriomas; 843,895 (10,842-1,676,948), 740,039 (77-1,280,000), 470 (61-880) and 2.5 (1-4) in dermoids; 3,485 (27.2-149,804), 9,007 (36.4-153,475), 1,631 (402-11,096) and 1 (0.5-2.5) in mucinous cysts, and 13,068 (5,300-43,767), 412 (1-142,700), 0.8 (0.4-5.3) and 2.3 (1-4) in the mixed histotype group. No significant between group differences were detected in serum marker levels. Patients in the mucinous cyst group had significantly lower CA 125 cystic fluid levels compared with women with endometriomas and dermoids (P<0.05). Fluid aspirate tumor marker measurements did not aid in the differential diagnosis of benign ovarian cysts, mainly due to the extremely wide scattering of values.
对74名年龄中位数为30岁（范围15至74岁）、因疑似良性附件囊肿而接受手术的连续女性患者，检测了其血清和囊液中CA 125、CA 19.9、癌胚抗原（CEA）和甲胎蛋白（AFP）的水平。44例子宫内膜异位囊肿患者中，CA 125、CA 19.9、CEA和AFP的血清水平中位数（范围）分别为46.5 IU/ml（4.3 - 406）、28.5 IU/ml（1 - 96.3）、1.4 ng/ml（0.5 - 3.5）和2.4 ng/ml（1 - 9.9）；11例皮样囊肿患者中分别为22.5（4.7 - 82）、4.9（1 - 226）、1.3（0.7 - 4.8）和4（0.5 - 10.5）；9例黏液性囊肿患者中分别为14（8.6 - 25.1）、3.2（1 - 6）、1（0.3 - 2.8）和3.7（1.9 - 6）；10例混合型组织学类型患者中分别为6.9（0.5 - 104）、18（1 - 132）、0.8（0.1 - 1.9）和2.1（1 - 5.4）。相应的囊液水平在子宫内膜瘤中为342,864（1,418 - 3,404,682）、228,000（117 - 2,500,000）、106（0.5 - 2,908）和1.3（0.4 - 51）；皮样囊肿中为843,895（10,842 - 1,676,948）、740,039（77 - 1,280,000）、470（61 - 880）和2.5（1 - 4）；黏液性囊肿中为3,485（27.2 - 149,804）、9,007（36.4 - 153,475）、1,631（402 - 11,096）和1（0.5 - 2.5）；混合型组织学类型组中为13,068（5,300 - 43,767）、412（1 - 142,700）、0.8（0.4 - 5.3）和2.3（1 - 4）。血清标志物水平在组间未检测到显著差异。黏液性囊肿组患者的CA 125囊液水平与子宫内膜瘤和皮样囊肿患者相比显著更低（P<0.05）。抽吸液肿瘤标志物测量对卵巢良性囊肿的鉴别诊断没有帮助，主要是因为数值分布极为分散。
