Gist D, Llorente J, Mayer J
Sharp Healthcare, Office of Continuing Medical Education, San Diego, CA 92123, USA.
West J Med. 1997 Jan;166(1):21-8.
Mammography is an important tool in the early detection of breast cancer, but its use has been criticized for stimulating the performance of unnecessary breast biopsies. We retrospectively reviewed the results of breast biopsies preceded by abnormal mammograms at a community hospital for three 5-month periods--baseline, postintervention, and follow-up--to determine the effectiveness of algorithm-based care for patients with an abnormal mammogram. Cases in which there was a definite or implied recommendation for biopsy by a radiologist revealed a baseline positive predictive value of 4% (2/45), a postintervention positive predictive value of 21% (9/42), and a follow-up phase positive predictive value of 18% (5/28). A Fisher's exact test of the preintervention and postintervention positive predictive values after an abnormal mammogram with a "recommendation for biopsy" was significant (n = 87, P = .023). A Kruskal-Wallis analysis of variance to determine if there had been an increase in the mean lesion size of breast cancers detected over the 3 study periods was not significant. The results of this study suggest that developing a clinical algorithm under the leadership of an opinion leader combined with continuing medical education efforts may be efficacious in reducing the incidence of unnecessary surgical procedures.
乳房X线摄影术是早期发现乳腺癌的一项重要工具,但它的使用因引发不必要的乳房活检而受到批评。我们回顾性地分析了一家社区医院在三个为期5个月的时间段(基线期、干预后期和随访期)内,由乳房X线摄影异常引发的乳房活检结果,以确定针对乳房X线摄影异常患者的基于算法的护理效果。放射科医生明确或暗示建议活检的病例显示,基线期阳性预测值为4%(2/45),干预后期阳性预测值为21%(9/42),随访期阳性预测值为18%(5/28)。对乳房X线摄影异常且有“活检建议”的干预前和干预后阳性预测值进行Fisher精确检验,结果具有显著性(n = 87,P = 0.023)。采用Kruskal-Wallis方差分析来确定在3个研究期内检测到的乳腺癌平均病变大小是否有所增加,结果无显著性。本研究结果表明,在意见领袖的领导下制定临床算法并结合继续医学教育努力,可能有助于降低不必要手术程序的发生率。