Hoh C K, Glaspy J, Rosen P, Dahlbom M, Lee S J, Kunkel L, Hawkin R A, Maddahi J, Phelps M E
Department of Molecular and Medical Pharmacology, Crump Institute of Biological Imaging, Los Angeles, California, USA.
J Nucl Med. 1997 Mar;38(3):343-8.
Accurate staging of Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) is important for treatment management. In this study, the utility of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) whole-body PET was evaluated as an imaging modality for initial staging or restaging of 7 HD and 11 NHL patients.
Whole-body PET-based staging results were compared to the patient's clinical stage based on conventional staging studies, which included combinations of CT of the chest, abdomen and pelvis, MRI scans, gallium scans, lymphangiograms, staging laparatomies and bone scans.
Accurate staging was performed in 17 of 18 patients using a whole-body PET-based staging algorithm compared to the conventional staging algorithm in 15 of 18 patients. In 5 of 18 patients, whole-body PET-based staging showed additional lesions not detected by conventional staging modalities, whereas conventional staging demonstrated additional lesions in 4 of 18 patients not detected by whole-body PET. The total cost of conventional staging was $66,292 for 16 CT chest scans, 16 CT abdominal/pelvis scans, three limited MRI scans, four bone scans, five gallium scans, two laparotomies and one lymphangiogram. In contrast, scans cost $36,250 for 18 whole-body PET studies and additional selected correlative studies: one plain film radiograph, one limited CT, one bone marrow scan, one upper GI and one endoscopy.
A whole-body FDG-PET-based staging algorithm may be an accurate and cost-effective method for staging or restaging HD and NHL.
准确分期霍奇金病（HD）和非霍奇金淋巴瘤（NHL）对于治疗管理很重要。在本研究中，评估了2-[18F]氟-2-脱氧-D-葡萄糖（FDG）全身PET作为7例HD和11例NHL患者初始分期或再分期的成像方式的效用。
基于全身PET的分期结果与基于传统分期研究的患者临床分期进行比较，传统分期研究包括胸部、腹部和骨盆CT、MRI扫描、镓扫描、淋巴管造影、分期剖腹术和骨扫描的组合。
与18例患者中的15例采用传统分期算法相比，18例患者中的17例使用基于全身PET的分期算法进行了准确分期。在18例患者中的5例中，基于全身PET的分期显示了传统分期方式未检测到的额外病变，而传统分期在18例患者中的4例中显示了全身PET未检测到的额外病变。传统分期的总成本为66,292美元，包括16次胸部CT扫描、16次腹部/骨盆CT扫描、3次有限的MRI扫描、4次骨扫描、5次镓扫描、2次剖腹术和1次淋巴管造影。相比之下，18次全身PET研究及其他选定的相关研究（1次平片X线摄影、1次有限CT、1次骨髓扫描、1次上消化道造影和1次内窥镜检查）的费用为36,250美元。
基于全身FDG-PET的分期算法可能是HD和NHL分期或再分期的准确且经济有效的方法。
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