18F-FDG 全身杂交PET在非霍奇金淋巴瘤分期中的应用

Whole-body hybrid PET with 18F-FDG in the staging of non-Hodgkin's lymphoma.

作者信息

Tatsumi M, Kitayama H, Sugahara H, Tokita N, Nakamura H, Kanakura Y, Nishimura T

机构信息

Division of Tracer Kinetics, Biomedical Research Center, Osaka University Graduate School of Medicine, Japan.

出版信息

J Nucl Med. 2001 Apr;42(4):601-8.

PMID:11337549

Abstract

UNLABELLED

PET with a double-head gamma camera (hybrid PET) is a new approach to tumor imaging with 18F-FDG. This study was conducted to clarify the feasibility of whole-body FDG hybrid PET in the staging of non-Hodgkin's lymphoma (NHL) in comparison with PET with a dedicated camera (dedicated PET) and to compare the results of both FDG studies with those of CT and 67Ga scanning as conventional imaging studies (CIS).

METHODS

Thirty patients with NHL were prospectively evaluated. The results of the imaging studies regarding detection of the sites involved and staging were compared with each other and with those of the reference standard based on the final overall clinical evaluation.

RESULTS

Of the total of 206 sites, whole-body FDG hybrid PET and dedicated PET detected 159 sites (77.2%) and 179 sites (86.9%), respectively. Eighteen of the 20 sites missed by hybrid PET alone consisted of lesions < 1.5 cm. Both FDG studies provided concordant staging results in all but 2 patients. CIS, on the other hand, detected 164 (79.6%) of the 206 sites, 137 of which were also detected by hybrid PET. Hybrid PET detected an additional 22 sites not found by CIS, whereas CIS detected 27 additional sites. Hybrid PET and CIS provided concordant staging results in 19 patients. Hybrid PET correctly staged NHL in 5 additional patients, whereas CIS correctly staged NHL in only 1 additional patient.

CONCLUSION

Whole-body FDG hybrid PET appeared to be an accurate method of staging NHL. Despite its poorer image quality compared with dedicated PET, hybrid PET provided NHL staging results comparable with those of dedicated PET. Hybrid PET also yielded results comparable with those of CIS. However, whole-body FDG hybrid PET is currently inadequate as a single modality for staging NHL and is complementary to CT.

摘要

未标注

使用双头伽马相机的PET（混合型PET）是一种利用18F-FDG进行肿瘤成像的新方法。本研究旨在阐明全身FDG混合型PET在非霍奇金淋巴瘤（NHL）分期中的可行性，并与使用专用相机的PET（专用PET）进行比较，同时将两种FDG研究的结果与作为传统成像研究（CIS）的CT和67Ga扫描结果进行比较。

方法

对30例NHL患者进行前瞻性评估。将关于受累部位检测和分期的成像研究结果相互比较，并与基于最终全面临床评估的参考标准结果进行比较。

结果

在总共206个部位中，全身FDG混合型PET和专用PET分别检测到159个部位（77.2%）和179个部位（86.9%）。仅混合型PET遗漏的20个部位中有18个是直径<1.5 cm的病变。除2例患者外，两种FDG研究在所有患者中均提供了一致的分期结果。另一方面，CIS在206个部位中检测到164个（79.6%），其中137个也被混合型PET检测到。混合型PET还检测到CIS未发现的另外22个部位，而CIS检测到另外27个部位。混合型PET和CIS在19例患者中提供了一致的分期结果。混合型PET在另外5例患者中正确分期了NHL，而CIS仅在另外1例患者中正确分期了NHL。