Macpherson M L, Chaffin M K, Carroll G L, Jorgensen J, Arrott C, Varner D D, Blanchard T L
Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843-4475, USA.
J Am Vet Med Assoc. 1997 Mar 15;210(6):799-803.
To compare effects of 3 oxytocin-based induction techniques on fetal and neonatal foals.
Prospective randomized controlled trial.
16 pregnant mares.
Parturition was induced in mares by use of 3 treatments: group 1, 75 U of oxytocin, IM; group 2, 15 U of oxytocin, IM, q 15 minutes, for a maximum of 75 U; group 3, 75 U of oxytocin in 1 L of 0.9% NaCl solution IV (1 U/min), for a maximum of 75 U. Blood gas values and indices of vitality were measured in foals, and variables describing parturition were measured in mares.
Group-3 mares had a shorter interval from administration of oxytocin to rupture of the chorioallantois (OTCA) than group-2 mares. More foals were abnormal when the interval from oxytocin administration to delivery of the foal (OTDE) was > or = 60 minutes. Arterial blood gas values, measurements of vitality, and plasma cortisol concentrations did not differ among foals in various treatment groups. Increased interval for OTCA and OTDE resulted in higher neonatal PaCO2, and a longer interval for OTCA resulted in lower arterial pH. Time required for birth was shorter in mares with a dilated cervix. More abnormal foals than normal foals were delivered after premature placental separation or dystocia. Abnormal foals took longer to stand and suckle than normal foals. Interval from delivery to suckling was positively correlated with OTCA, OTDE, and PaCO2.
Method of oxytocin-induced parturition did not impact neonatal outcome. Interval from induction until parturition, degree of cervical dilatation, and intrapartum complications influenced induction success.
比较3种基于催产素的引产技术对胎儿和新生马驹的影响。
前瞻性随机对照试验。
16匹怀孕母马。
对母马采用3种治疗方法引产：第1组，肌内注射75 U催产素；第2组，肌内注射15 U催产素，每15分钟1次，最多75 U；第3组，将75 U催产素加入1 L 0.9%氯化钠溶液中静脉注射（1 U/分钟），最多75 U。测量马驹的血气值和活力指标，并测量母马与分娩相关的变量。
第3组母马从注射催产素到绒毛膜尿囊破裂（OTCA）的间隔时间比第2组母马短。当从注射催产素到马驹分娩（OTDE）的间隔时间≥60分钟时，更多马驹出现异常。不同治疗组马驹的动脉血气值、活力测量值和血浆皮质醇浓度无差异。OTCA和OTDE间隔时间延长导致新生儿PaCO2升高，OTCA间隔时间延长导致动脉pH值降低。宫颈扩张的母马分娩所需时间较短。胎盘早剥或难产分娩后出现异常马驹的数量多于正常马驹。异常马驹站立和吮乳所需时间比正常马驹长。从分娩到吮乳的间隔时间与OTCA、OTDE和PaCO2呈正相关。
催产素引产方法不影响新生儿结局。从引产到分娩的间隔时间、宫颈扩张程度和产时并发症影响引产成功率。
