Petit C, Hoffmann P, Souchard J P, Nepveu F, Labidalle S
Laboratoire de Synthèse, Physico-Chimie et Radiobiologie-JE 175, Université Paul-Sabatier, Faculté des Sciences Pharmaceutiques, Toulouse, France.
C R Seances Soc Biol Fil. 1996;190(5-6):641-50.
Until recently, nitric oxide (NO.) was considered as a toxic radical, but it appears now as an essential messenger implicated in a wide range of biological processes, including immune system, cardiovascular system, and nervous system. An aspect of NO. metabolism in vivo is the formation of a variety of high and low molecular weight nitrosothiols. S-nitrosocysteine and S-nitrosoglutathione are among the biologically derived S-nitrosothiols that are postulated to be carriers of NO.. Although most of the S-nitrosothiols are unstable and spontaneously break down to produce NO. and a disulfide, some of them, including protein thiols, can show significant stability. These molecules are able to convey nitric oxide, that is, to keep, to carry, and then to generate NO. in physiological media, and might display pharmacological effects as potential vasodilators or neuroprotectors. Here, we present the development of new thionitrites R-S-NO having intrinsic antioxidant properties. We report the preparation, the characterization, and the stability studies in aqueous solutions of S-nitroso derivatives of dihydro-alpha-lipoic acid, known for its antioxidant properties.
直到最近，一氧化氮（NO.）还被认为是一种有毒的自由基，但现在它似乎是一种重要的信使，参与包括免疫系统、心血管系统和神经系统在内的广泛生物过程。体内NO.代谢的一个方面是形成各种高分子量和低分子量的亚硝基硫醇。S-亚硝基半胱氨酸和S-亚硝基谷胱甘肽是推测为NO.载体的生物衍生亚硝基硫醇。尽管大多数亚硝基硫醇不稳定，会自发分解产生NO.和二硫化物，但其中一些，包括蛋白质硫醇，可表现出显著的稳定性。这些分子能够传递一氧化氮，即在生理介质中保存、携带并随后产生NO.，并且可能作为潜在的血管舒张剂或神经保护剂发挥药理作用。在此，我们展示了具有内在抗氧化特性的新型硫亚硝酸盐R-S-NO的研发情况。我们报告了以其抗氧化特性而闻名的二氢-α-硫辛酸的S-亚硝基衍生物在水溶液中的制备、表征和稳定性研究。
