[Morphological indicators of the peripheral blood leukocytes at different periods of development of myocardial infarct (experimental study)].

The morpho-functional features of peripheral blood leukocytes were studied in 50 rabbits with experimental myocardial infarction at various intervals after ligation of the anterior interventricle artery. Changes in the leukocytes were compared with the morphological picture of myocardial infarction. In the acute period of experimental myocardial infarction not only quantitative changes were found to occur but also functional values of leukocytes changes: the content of glycogen and the activities of peroxidase and phagocytic activity of granulocytes were reduced, while the activity of alkaline phosphatase increased. Electron microscopic examinations of lymphocytes revealed ultrastructural changes in mitochondria. In the subacute period of the disease some of the values showed a trend for normalization. In the period of recuperation when the zone of infarction in rabbits is replaced by crude fiber connective tissue all the values under study in the peripheral blood became normal. The exceptions were the animals with extensive as well as complicated myocardial infarctions.