博尔纳病病毒抗体与精神分裂症的缺陷综合征

Borna disease virus antibodies and the deficit syndrome of schizophrenia.

作者信息

Waltrip R W, Buchanan R W, Carpenter W T, Kirkpatrick B, Summerfelt A, Breier A, Rubin S A, Carbone K M

机构信息

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland at Baltimore, Catonsville 21228, USA.

出版信息

Schizophr Res. 1997 Feb 28;23(3):253-7. doi: 10.1016/s0920-9964(96)00114-4.

DOI:10.1016/s0920-9964(96)00114-4

PMID:9075304

Abstract

We detected anti-Borna disease virus (BDV) antibodies at a 14.4% rate in patients with schizophrenia. The hypothesis of a higher rate of BDV seropositivity in deficit syndrome was borne out in a subset of 64 patients categorized according to the Schedule for the Deficit Syndrome with 5/15 seropositive deficit and 4/49 seropositive nondeficit (p < 0.05). This suggests that the antibodies and possibly a BDV-like virus are pathogenetically linked to this form of schizophrenia.

摘要

我们在精神分裂症患者中检测到抗博尔纳病病毒（BDV）抗体的比率为14.4%。在根据缺陷综合征量表分类的64例患者亚组中，证实了缺陷综合征中BDV血清阳性率较高的假设，其中5例有缺陷者血清阳性，49例无缺陷者中有4例血清阳性（p<0.05）。这表明这些抗体以及可能一种类似BDV的病毒在发病机制上与这种形式的精神分裂症有关。