Shibata R, Siemon C, Rizvi T A, Matano T, Satterfield W C, Lane H C, Martin M A
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
AIDS Res Hum Retroviruses. 1997 Mar 20;13(5):377-81. doi: 10.1089/aid.1997.13.377.
Following resolution of a primary HIV-1 infection initially induced by inoculating a mixture of three different virus strains, a chimpanzee was exposed to both immunostimulatory and immunosuppressive agents in an attempt to assess the contributions of different components of the immune system in suppressing circulating virus. The infusion of human leukocytes as an xenogeneic stimulus induced the replication of one of the input virus strains that had not previously been isolated or detected by PCR. The administration of high-dose, 17-day courses of corticosteroids resulted in coordinate and transient increases of each of the three viruses present in the original inoculum and elevation of HIV-1-specific ELISA antibody levels. Steroids administered to a second chimpanzee, chronically infected with a single HIV-1 isolate, also induced elevations of cell-associated virus. These results highlight the intimate relationship between immune system activation/immunosuppression and HIV replication in an animal model.
在通过接种三种不同病毒株的混合物最初诱导的原发性HIV-1感染消退后，一只黑猩猩被暴露于免疫刺激剂和免疫抑制剂中，以评估免疫系统不同成分在抑制循环病毒中的作用。输注人白细胞作为异种刺激物诱导了一种先前未通过PCR分离或检测到的输入病毒株的复制。给予高剂量、为期17天的皮质类固醇疗程导致原始接种物中存在的三种病毒中的每一种都出现协同和短暂的增加，以及HIV-1特异性ELISA抗体水平的升高。给予另一只慢性感染单一HIV-1分离株的黑猩猩类固醇，也诱导了细胞相关病毒的升高。这些结果突出了动物模型中免疫系统激活/免疫抑制与HIV复制之间的密切关系。
