Watanabe D, Barlow D P
The Netherlands Cancer Institute (H5), Amsterdam.
Genes Cells. 1996 Sep;1(9):795-802. doi: 10.1046/j.1365-2443.1996.d01-276.x.
This review has surveyed the current literature on random and imprinted monoallelic expression from the unusual perspective of considering that these two forms of monoallelic expression (MAE) may be regulated by similar mechanisms. The true extent of genes which show MAE is not yet known. Imprinted MAE is thought to involve 0.1-0.2% of mammalian genes, while the number of genes in the random MAE category cannot at present be predicted since very few genes have been examined with assays that distinguish parental transcripts in single cells. The perspective adopted in this review is speculative since only one gene (XIST) is known which displays both random and imprinted MAE. However, a recent report that H19 may also show random allelic expression, suggests that MAE should be further investigated as a gene regulation mechanism in mammals.
本综述从一个不同寻常的角度审视了当前关于随机和印记单等位基因表达的文献，即认为这两种单等位基因表达形式（MAE）可能受相似机制调控。显示MAE的基因的实际数量尚不清楚。印记MAE被认为涉及0.1 - 0.2%的哺乳动物基因，而随机MAE类别中的基因数量目前无法预测，因为很少有基因通过能区分单细胞中亲本转录本的检测方法进行研究。本综述所采用的观点具有推测性，因为已知只有一个基因（XIST）同时表现出随机和印记MAE。然而，最近一份关于H19也可能显示随机等位基因表达的报告表明，MAE作为哺乳动物中的一种基因调控机制应进一步研究。
