绵羊母体输注硝酸甘油对胎儿及母体血液动力学和代谢的影响。

Fetal and maternal hemodynamic and metabolic effects of maternal nitroglycerin infusions in sheep.

作者信息

Bootstaylor B S, Roman C, Parer J T, Heymann M A

机构信息

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, USA.

出版信息

Am J Obstet Gynecol. 1997 Mar;176(3):644-50. doi: 10.1016/s0002-9378(97)70563-5.

DOI:10.1016/s0002-9378(97)70563-5

PMID:9077622

Abstract

OBJECTIVES

We previously demonstrated effective tocolysis with nitroglycerin in laboring sheep. In this study we evaluated maternal and fetal circulatory effects of nitroglycerin.

STUDY DESIGN

Vascular catheters and an umbilical Doppler flow transducer were placed in eight ewes. Nitroglycerin was infused maternally over 30 minutes at 1.5, 2.5, 5.0, and 10 microg x kg maternal weight(-1) x min(-1). We recorded maternal and fetal variables before, at the end of each 30-minute infusion period, and 30 minutes later. Fetal regional flow distribution was measured with microspheres. Fetal oxygen, glucose, and lactate uptake were calculated. Data were analyzed by analysis of variance.

RESULTS

There were no changes in fetal blood gas values, oxygen or substrate uptake, umbilical flow, output distribution, pressures, or heart rate. Maternal mean pressure fell and heart rate increased concomitantly. Maternal blood gases were unchanged.

CONCLUSION

Nitroglycerin at tocolytic and greater doses had no adverse effects on fetal circulatory function during a 2-hour infusion.

摘要

目的

我们之前已证明硝酸甘油对分娩中的绵羊有有效的保胎作用。在本研究中，我们评估了硝酸甘油对母胎循环的影响。

研究设计

在8只母羊身上放置血管导管和脐动脉多普勒血流换能器。以1.5、2.5、5.0和10微克×千克母羊体重⁻¹×分钟⁻¹的剂量，在30分钟内对母羊进行硝酸甘油静脉输注。在每次30分钟输注期结束时及30分钟后，记录母胎各项变量。用微球测量胎儿局部血流分布。计算胎儿氧、葡萄糖和乳酸摄取量。数据采用方差分析进行分析。