Maternal and fetal side effects of tocolysis using transdermal nitroglycerin or intravenous fenoterol combined with magnesium sulfate.
作者信息
Schleussner Ekkehard, Möller Arne, Gross Walter, Kähler Christiane, Möller Udo, Richter Sabine, Seewald Hans Joachim
机构信息
Department of Obstetrics and Gynaecology, Friedrich Schiller University Jena, Bachstrasse18, 07740, Jena, Germany.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2003 Jan 10;106(1):14-9. doi: 10.1016/s0301-2115(02)00197-5.
OBJECTIVE
To compare the maternal and fetal side effects of transdermal nitroglycerin and intravenous fenoterol combined with magnesium sulfate in a prospective randomised study.
STUDY DESIGN
Fifty pregnant women between 27 and 35 weeks of gestation with preterm labour were treated with either nitroglycerin (0.4-0.8 mg/h) or fenoterol (60 - 120 microg/h). Outcome parameters were (1) the effects on fetal and maternal heart frequency (FHF/MHF) and blood pressure, and (2) subjective experiences of adverse effects assessed by utilising a questionnaire.
RESULTS
In the fenoterol group, elevated mean MHF, FHF and systolic blood pressure were recorded compared to nitroglycerin. Fewer maternal side effects were reported in the nitroglycerin group. Palpitations (82%), tremor (68%) and restlessness (64%) were most common in the fenoterol group (two drop-outs), whereas nitroglycerin caused headaches in 71% of the cases (four drop-outs).
CONCLUSION
Transdermal nitroglycerin appears to be a safe therapy for the mother and fetus and is a promising new option for the treatment of preterm labour.
Zotero 插件