Nagradova N K, Grozdova I D
Biokhimiia. 1977 Jul;42(7):1155-66.
The binding of antibodies to enzymes-antigens markedly affects the activity and structure of the latters. The mechanisms of activation and inhibition of enzymes by antibodies and the use of immunochemical methods for the study of the active sites structure, conformational changes during interaction with substrates and other ligands and the quaternary structure of enzymes are discussed.
抗体与酶 - 抗原的结合显著影响后者的活性和结构。本文讨论了抗体对酶的激活和抑制机制,以及免疫化学方法在研究酶活性位点结构、与底物及其他配体相互作用过程中的构象变化和酶的四级结构方面的应用。