[人二倍体细胞和实验小鼠衰老过程中葡萄糖-6-磷酸脱氢酶的稳定性]
[Stability of glucose-6-phosphate dehydrogenase in aging of human diploid cells and the laboratory mouse].
作者信息
Mamaev V B, Obukhova L K, Volkova N M, Alekseev S B, Avakova A N, Stepanova L G
出版信息
Biokhimiia. 1977 Jul;42(7):1261-5.
PMID:907796
Abstract
Glucose 6-phosphate dehydrogenase (E. C. 1.1.1.49) was found to be inactivated by 30% for 25 min the incubation at 37 degrees C in extracts of human diploid cells and mouse liver, and the stability of the enzyme was found to reduce in aging of human diploid cells and mouse. The stability of dehydrogenase of mice treated with "geroprotector", 2-ethyl-6-methyl-3-hydroxypyridine, exceeds the control level.
摘要
发现葡萄糖-6-磷酸脱氢酶（E.C.1.1.1.49）在人二倍体细胞和小鼠肝脏提取物中于37℃孵育25分钟后失活30%，并且发现该酶的稳定性在人二倍体细胞和小鼠衰老过程中降低。用“老年保护剂”2-乙基-6-甲基-3-羟基吡啶处理的小鼠的脱氢酶稳定性超过对照水平。
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