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[实验性烧伤疾病中肝脏糖酵解氧化还原紊乱]

[Disorder of glycolytic redox in the liver in experimental burn disease].

作者信息

Slobodin V B, Lifshits R I, Sobolevskaia T M

出版信息

Biull Eksp Biol Med. 1977 Aug;84(8):171-3.

PMID:907820
Abstract

The authors present the results of studies of the intensity of glycolytic oxidoreduction in the rat liver 3, 6, 12 and 24 days after the reproduction of experimental burn disease. This disease proved to lead to reduction of the glyceral-phosphate dehydrogenase activity and to decrease of 3-phosphoglyceric acid formation in the burned animals' liver, mostly expressed during burn toxemia (the 6th day). The limiting factor of the course of this reaction after the burn was the lack of NAD in the cell. Abnormality of the course of the investigated reaction was one of the reasons for reduced intensity during the glycolytic way of carbohydrate decay as a whole and for decrease of the energetic role of glucose in burn disease.

摘要

作者展示了在实验性烧伤疾病复制后3天、6天、12天和24天大鼠肝脏中糖酵解氧化还原强度的研究结果。事实证明,这种疾病会导致烧伤动物肝脏中甘油磷酸脱氢酶活性降低以及3 - 磷酸甘油酸生成减少,这在烧伤毒血症期间(第6天)表现最为明显。烧伤后该反应过程的限制因素是细胞内缺乏烟酰胺腺嘌呤二核苷酸(NAD)。所研究反应过程的异常是整个碳水化合物分解糖酵解途径强度降低以及烧伤疾病中葡萄糖能量作用下降的原因之一。

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