内含子与基因进化。

Introns and gene evolution.

作者信息

de Souza S J, Long M, Gilbert W

机构信息

Biological Laboratories, Harvard University, Cambridge, MA 02138, USA.

出版信息

Genes Cells. 1996 Jun;1(6):493-505. doi: 10.1046/j.1365-2443.1996.d01-264.x.

DOI:10.1046/j.1365-2443.1996.d01-264.x

PMID:9078380

Abstract

In one scenario of gene evolution, exon shuffling has a fundamental role in increasing gene diversity. As DNA sequences accumulate in the databases, the picture of the intron/exon structures of genes becomes more and more clear. We discuss in this review some features of this picture that suggest that introns have been present since the early stages of evolution, and that exon shuffling was a fundamental process in the construction of ancient as well as modern genes.

摘要

在基因进化的一种情形中，外显子重排对于增加基因多样性起着根本性作用。随着DNA序列在数据库中不断积累，基因的内含子/外显子结构图景变得越来越清晰。在本综述中，我们讨论了这一图景的一些特征，这些特征表明内含子自进化早期就已存在，并且外显子重排是构建古代和现代基因的一个基本过程。