Benediktsson R, Edwards C R
University Department of Medicine, Western General Hospital, Edinburgh, U.K.
Essays Biochem. 1996;31:23-36.
11 beta-HSD catalyses the interconversion of active and inactive corticosteroids and exists as two isoforms with less than 30% amino acid homology. The bi-directional NADP-dependent type 1 enzyme appears to function as a tissue-specific glucocorticoid provider. The uni-directional NAD-dependent type 2 enzyme functions as a tissue-specific glucocorticoid protector. The syndrome of AME is caused by mutations in the gene of 11 beta-HSD2. Placental 11 beta-HSD2 is a barrier to growth-retarding maternal glucocorticoids and may play a key role in prenatal programming of hypertension.
11β-羟基类固醇脱氢酶催化活性和非活性皮质类固醇的相互转化，以两种氨基酸同源性低于30%的同工型存在。双向依赖烟酰胺腺嘌呤二核苷酸磷酸（NADP）的1型酶似乎作为一种组织特异性糖皮质激素供应者发挥作用。单向依赖烟酰胺腺嘌呤二核苷酸（NAD）的2型酶作为一种组织特异性糖皮质激素保护者发挥作用。表观盐皮质激素过多综合征（AME）由11β-羟基类固醇脱氢酶2（11β-HSD2）基因突变引起。胎盘11β-HSD2是阻碍母体糖皮质激素导致胎儿生长迟缓的屏障，可能在高血压的产前编程中起关键作用。
