IgG Fc受体及FcγR导向免疫疗法的临床意义
Clinical significance of IgG Fc receptors and Fc gamma R-directed immunotherapies.
作者信息
Deo Y M, Graziano R F, Repp R, van de Winkel J G
机构信息
Medarex Inc., Annandale, NJ 08801, USA.
出版信息
Immunol Today. 1997 Mar;18(3):127-35. doi: 10.1016/s0167-5699(97)01007-4.
PMID:9078685
Abstract
Fc receptors for IgG (Fc gamma Rs) can trigger the inflammatory, cytotoxic and hypersensitivity functions of immune effector cells. Activation or deactivation of effector cells via Fc gamma Rs can be exploited to develop novel therapies for cancer, infectious diseases and autoimmune disorders. Initial results of clinical trials for several Fc gamma R-directed immunotherapies show the potential promise of this approach.
摘要
免疫球蛋白G的Fc受体（FcγRs）可触发免疫效应细胞的炎症、细胞毒性和超敏反应功能。通过FcγRs激活或失活效应细胞可用于开发针对癌症、传染病和自身免疫性疾病的新型疗法。几种针对FcγR的免疫疗法的临床试验初步结果显示了这种方法的潜在前景。
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