Goddard A W, Charney D S
Department of Psychiatry, Yale University School of Medicine, New Haven, USA.
J Clin Psychiatry. 1997;58 Suppl 2:4-11; discussion 11-2.
Panic disorder is a common psychiatric illness that causes considerable short- and long-term morbidity. Although drug treatment and cognitive behavior therapy are beneficial, the etiology of panic disorder and the mechanisms of effective treatment remain unclear. Developments in the preclinical neuroanatomy and neurophysiology of neuronal structures relevant to fear and anxiety promise to provide fresh insights into the neurobiology of panic. In this article, we propose a functional neuroanatomic model of fear and anxiety and review brain imaging studies of panic disorder with this model in mind. In addition, we discuss the implications of integrating functional neuroanatomy and the clinical neurochemistry of panic disorder. An integrated neurobiology of panic disorder will provide a broader conceptual framework with which to tackle the complex questions about the pathophysiology and treatment of this condition.
惊恐障碍是一种常见的精神疾病，会导致严重的短期和长期发病。尽管药物治疗和认知行为疗法有益，但惊恐障碍的病因及有效治疗机制仍不明确。与恐惧和焦虑相关的神经元结构在临床前神经解剖学和神经生理学方面的进展有望为惊恐的神经生物学提供新的见解。在本文中，我们提出了一个恐惧和焦虑的功能性神经解剖模型，并在考虑该模型的情况下回顾了惊恐障碍的脑成像研究。此外，我们还讨论了整合惊恐障碍的功能性神经解剖学和临床神经化学的意义。惊恐障碍的综合神经生物学将提供一个更广泛的概念框架，用以解决有关该疾病病理生理学和治疗的复杂问题。
