Thorén-Tolling K, Jönsson L
Can J Comp Med. 1977 Jul;41(3):318-25.
Histochemical studies were performed on tissues from piglets of different ages treated orally with iron dextran soon after birth. The mucosal cells in the distal region of the small intestine were heavily laden with stainable iron granules during the first three days after the iron administration. The absorptive epithelial cells are desquamated within seven to ten days after birth. Consequently, the number of iron granules gradually diminishes during the first seven days after treatment and no iron granules are demonstrated 12 days after the administration of iron. The iron dextran complex is pinocytosed in newborn piglets and then transported via the lymphatic system. Thus the sinusoidal lining cells of the body and mesenteric lymph nodes are already heavily laden with iron granules 24 hours after oral treatment. This iron store is released only slowing during the first weeks of life. Great amounts of iron granules are demonstrated in the liver and spleen macrophages during the first week after the administration of iron. Due to the rapid utilization of iron in growing piglets these iron stores diminish sharply during the weeks following birth. The distribution of stainable iron in the lymph nodes, liver and spleen seven days after intramuscular injection of iron dextran in newborn piglets was comparable to that for oral administration at that stage of the experiment.
对出生后不久经口服右旋糖酐铁处理的不同年龄仔猪的组织进行了组织化学研究。在给予铁剂后的头三天，小肠远端区域的黏膜细胞中充满了可染色的铁颗粒。吸收性上皮细胞在出生后七至十天内脱落。因此，在治疗后的头七天内，铁颗粒的数量逐渐减少，在给予铁剂12天后未发现铁颗粒。右旋糖酐铁复合物在新生仔猪中通过胞饮作用进入细胞，然后通过淋巴系统运输。因此，口服治疗24小时后，身体的窦状隙衬里细胞和肠系膜淋巴结中已充满铁颗粒。这种铁储存仅在生命的最初几周缓慢释放。在给予铁剂后的第一周，肝脏和脾脏巨噬细胞中可见大量铁颗粒。由于生长中的仔猪对铁的快速利用，这些铁储存在出生后的几周内急剧减少。在新生仔猪肌肉注射右旋糖酐铁七天后，淋巴结、肝脏和脾脏中可染色铁的分布与实验该阶段口服给药的情况相当。
