Dice P F, Cooley P L
Animal Eye Clinic, Seattle, Washington 98105, USA.
Equine Vet J Suppl. 1990 Sep(10):18-21. doi: 10.1111/j.2042-3306.1990.tb04704.x.
This report involves a retrospective study of five horses with an unusual form of progressive peripheral corneal ulcers. These ulcers were located at the perilimbal region of the cornea and spread both centripetally to mid periphery and circumferentially. Lipping of the epithelial edge was observed often. The depth ranged from superficial to mid stroma. Patients ranged from two and a half to eight years, both sexes, and were referred after a variety of antibacterial therapy. Histories were similar in that all ulcers were initially located adjacent to the limbus in one or more quadrants. No trauma was known to antedate the corneal disease and the patients were in good general health. Conjunctivectomy was performed in three patients which revealed an abundance of plasma cells and lymphocytes. All five cases were negative for a specific bacterial pathogen. Patients responded to a variety of treatment modalities: topical corticosteroid, surgical debridement, therapeutic soft contact lens (TSCL), and/or conjunctivectomy.
本报告涉及对五匹马进行的回顾性研究，这些马患有一种不寻常形式的进行性周边角膜溃疡。这些溃疡位于角膜的角膜缘区域，向心性扩散至中周边部并呈环形蔓延。上皮边缘常可见唇样改变。溃疡深度从浅表至基质中层不等。病马年龄在两岁半至八岁之间，雌雄均有，在接受各种抗菌治疗后前来就诊。病史相似之处在于，所有溃疡最初均位于一个或多个象限的角膜缘附近。在角膜疾病发生之前未发现有外伤史，且病马总体健康状况良好。对三匹马进行了结膜切除术，结果显示有大量浆细胞和淋巴细胞。所有五例均未检测出特定的细菌病原体。病马对多种治疗方式有反应：局部使用皮质类固醇、手术清创、治疗性软性接触镜（TSCL）和/或结膜切除术。
