Chretien I, Marcuz A, Fellah J, Charlemagne J, Du Pasquier L
Basel Institute for Immunology, Switzerland.
Eur J Immunol. 1997 Mar;27(3):763-71. doi: 10.1002/eji.1830270327.
cDNA of the T cell receptor beta (TCRB) have been isolated from the anuran amphibian Xenopus and they show strong structural homology to TCRB sequences of other vertebrates. Ten BV families, two D segments, ten J segments, and a single C region have been defined so far. Each V family consists of one to two members per haploid genome. A unique feature of the Xenopus TCRB constant region is the lack of N-linked carbohydrate glycosylation sites. The recombination signal sequences suggest that the mechanism of rearrangements are identical to those of mammals. The locus is inherited in a diploid manner despite the pseudotetraploidy of the Xenopus laevis and X. gilli used in this study.
已从无尾两栖动物非洲爪蟾中分离出T细胞受体β（TCRB）的cDNA，它们与其他脊椎动物的TCRB序列具有很强的结构同源性。到目前为止，已确定了10个BV家族、2个D片段、10个J片段和1个C区域。每个V家族在单倍体基因组中由1至2个成员组成。非洲爪蟾TCRB恒定区的一个独特特征是缺乏N-连接碳水化合物糖基化位点。重组信号序列表明重排机制与哺乳动物相同。尽管本研究中使用的非洲爪蟾和吉利爪蟾是假四倍体，但该基因座以二倍体方式遗传。
