Roux C, Borodkine R, Joanne C, Bresson J L, Agnani G
Centre de Fécondation in vitro du Centre Hospitalier Universitaire Saint-Jacques, Besançon, France.
Hum Reprod Update. 1995 Sep;1(5):488-96. doi: 10.1093/humupd/1.5.488.
A previous study detailed the morphometric characteristics of living in-vitro fertilized human pronuclear zygotes and cleaved embryos. A comparison of the different embryo cell stages confirmed the asynchronous division process during early embryo development. Global results showed no evidence of morphometrical differences between embryo subpopulations according to their classical microscopical grading. In this report, further information on illumination of human embryos and analysis of image processing is given. Some examples of embryo images belonging to a normal asynchronous division process are shown. A new parameter was retrospectively attributed to each cleaved embryo based on whether or not they were considered to have undergone asynchronous division that qualified as normal. A non-parametric analysis of this preliminary sample showed that this qualifier was correlated with implantation and acted complementarily with embryo grading. In conclusion, the asynchronous division process qualified as normal and its deviations seem to be a new parameter to take into account during embryo scoring.
先前的一项研究详细阐述了体外受精的人类原核受精卵和分裂期胚胎的形态测量特征。对不同胚胎细胞阶段的比较证实了早期胚胎发育过程中的异步分裂过程。总体结果显示，根据经典显微镜分级，胚胎亚群之间没有形态测量差异的证据。在本报告中，给出了关于人类胚胎照明和图像处理分析的进一步信息。展示了一些属于正常异步分裂过程的胚胎图像示例。根据每个分裂期胚胎是否被认为经历了符合正常标准的异步分裂，回顾性地为其赋予了一个新参数。对这个初步样本的非参数分析表明，这个限定因素与着床相关，并且与胚胎分级起到互补作用。总之，符合正常标准的异步分裂过程及其偏差似乎是胚胎评分过程中需要考虑的一个新参数。
