Nagatomo I, Akasaki Y, Uchida M, Takigawa M
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan.
Neuroreport. 1997 Jan 20;8(2):391-4. doi: 10.1097/00001756-199701200-00001.
This study was undertaken to evaluate the effect of ethanol intake on the anticonvulsive effects of Zonisamide (ZNS), a sulfonamide derivative. EL mice, which are highly susceptible to seizures, were given a 10% ethanol solution ad lib for 1-4 weeks. In mice given ethanol for 4 weeks, seizures were not suppressed by ZNS at a dose of 75 mg kg-1, i.p. Serum ZNS concentrations following ethanol consumption for 1-4 weeks were higher than in untreated mice; however, brain ZNS concentrations following ethanol consumption were lower than those in untreated mice. These results suggest that alcohol intake decreases the brain concentration of ZNS, but not the serum concentration.
