Henry C, Tanti J F, Grémeaux T, Morin C, Van Obberghen E, Comet M, Le Marchand-Brustel Y
Institut National de la Santé ET DE LA Recherche Medicale, Inserm U 145, Faculté Médicine, Nice, France.
Nucl Med Biol. 1997 Jan;24(1):99-104. doi: 10.1016/s0969-8051(96)00182-5.
6-deoxy-6-iodo-D-glucose (6-DIG) was rapidly taken up by adipocytes. Insulin increased 6-DIG transport in adipocytes isolated from both rats and mice. This stimulation was more important in rat than in mouse adipocytes, in agreement with their respective amount of Glut 4 transporters. In two insulin resistant states, the biological behavior of 6-DIG and 3-O-methyl-D-glucose was similar. These results indicated that 6-DIG, which was transported into the cells via the glucose transporters, could be potentially useful to measure modifications of glucose transport.
