Pihl E, Malahy M A, Khankhanian N, Hersh E M, Mavligit G M
Cancer Res. 1977 Nov;37(11):4145-9.
Histological slides of primary tumors and regional lymph nodes from 134 unselected patients operated on for colorectal carcinoma of Dukes' Class B were assessed semiquantitatively for the presence of perivascular lymphocyte cuffing in the muscular layers and pericolic/subserosal fat immediately subjacent to the tumors and for paracortical hyperplasia in the regional lymph nodes. These two immunomorphological features related significantly to each other (p less than 0.05), and their combined presence related signifcantly to favorable disease-free interval (p = 0.02) and to survival (p = 0.04), making possible the identification of a subgroup of approximately one-third of Dukes' B class patients with an estimated better than 85% chance for 5-year recurrence-free survival.
对134例未经过挑选、接受手术治疗的杜克B期结肠癌患者的原发性肿瘤及区域淋巴结的组织学切片进行半定量评估，观察肿瘤紧邻部位肌层和结肠旁/浆膜下脂肪中血管周围淋巴细胞套袖的存在情况，以及区域淋巴结中副皮质增生情况。这两种免疫形态学特征之间存在显著相关性（p<0.05），它们的共同存在与良好的无病生存期（p = 0.02）和生存率（p = 0.04）显著相关，从而有可能识别出约三分之一的杜克B期患者亚组，其5年无复发生存率估计超过85%。
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