Donnenberg M S, Kaper J B, Finlay B B
Divn of Infectious Diseases, University of Maryland School of Medicine, Baltimore 21201, USA.
Trends Microbiol. 1997 Mar;5(3):109-14. doi: 10.1016/S0966-842X(97)01000-7.
The pathogenesis of enteropathogenic Escherichia coli (EPEC) infection is emerging as a paradigm for a multistage microorganism-host cell interaction. Both type IV fimbriae and a type III secretion apparatus play principal roles in interactions between the bacteria and host cells. Recent data suggest that bacteria-induced signal transduction activates the receptor that allows tenacious adherence of the bacteria to the host cell surface.
肠致病性大肠杆菌（EPEC）感染的发病机制正逐渐成为微生物与宿主细胞多阶段相互作用的范例。IV型菌毛和III型分泌系统在细菌与宿主细胞的相互作用中都起着主要作用。最近的数据表明，细菌诱导的信号转导激活了使细菌牢固粘附于宿主细胞表面的受体。
