Watanabe K, Hasegawa M, Saito Y, Takayama S
Clin Allergy. 1977 May;7(3):263-71. doi: 10.1111/j.1365-2222.1977.tb01451.x.
The changes in peroxidase of the granules of eosinophils were examined in cells in the nasal mucous membranes of persons allergic to house dust. There was a slight leakage of peroxidase from eosinophil granules immediately after placing an antigen-treated disc (house dust, Torii, 2560 microgram/disc) on the nasal mucous membrane. Leakage of peroxidase from the eosinophil granules into the cytoplasm, and extracellular release from some eosinophils, was greater 20 min after provocation, than at 30 sec. There were two forms of peroxidase release from the plasma membrane. In one, the granule membrane fused with the plasma membrane and the peroxidase was released from the cell through destruction of the two fused membranes. This was considered to be active secretion. In the other form, the plasma membrane was damaged by peroxidase released from the granules into the cytoplasm. This was considered to be passive release following degeneration of the cell.
对屋尘过敏者鼻黏膜细胞中嗜酸性粒细胞颗粒过氧化物酶的变化进行了研究。将经抗原处理的圆片（屋尘，鸟居，2560微克/片）置于鼻黏膜上后，嗜酸性粒细胞颗粒立即出现轻微的过氧化物酶泄漏。激发后20分钟，过氧化物酶从嗜酸性粒细胞颗粒泄漏到细胞质中以及从一些嗜酸性粒细胞向细胞外释放的情况比30秒时更严重。过氧化物酶从质膜释放有两种形式。一种是颗粒膜与质膜融合，过氧化物酶通过两层融合膜的破坏从细胞中释放出来。这被认为是主动分泌。另一种形式是质膜因颗粒释放到细胞质中的过氧化物酶而受损。这被认为是细胞变性后的被动释放。
