Synthesis of some new 2-methyl-4-(substituted benzylidene)1-phenyl-1,2,4 triazolo (3,4,-b) 1,4,5 thiadiazole as potential AChE inhibitory agents.

4-(1-aminophenyl)-1,2,4-triazolo[3,4,-b]1,3,4-thiadiozole (2) was prepared by treatment of 4-(1-aminophenyl)-5-mercapto-4-amino-1,2,4-S-triazole with carbondisulfide and KOH in methanol. This on further reaction with different 2-methyl-4-(substituted benzylidene)-oxazolin-5-ones gave 2-methyl-4-(substituted benzylidene)-1-phenyl-1,2,4[triazolo[3,4,-b]1,3,4-thiadiozoles. The compounds were screened for AChE inhibitory activity.