Hochstenbag M M, Snoep G, Cobben N A, Schols A M, Thunnissen F B, Wouters E F, ten Velde G P
Department of Pulmonology, University Hospital, Maastricht, Netherlands.
Eur J Cancer. 1996 May;32A(5):779-82. doi: 10.1016/0959-8049(95)00624-9.
In small cell lung cancer (SCLC), bone marrow metastases are frequently detected by bone scintigraphy (BS) and/or unilateral bone marrow biopsy and aspiration (BMBA). In this study, the value of magnetic resonance imaging (MRI) of thoracic spine and pelvis was compared with BS and BMBA and its clinical implication was evaluated in 42 patients with SCLC. Patients were staged (including BS, BMBA, CT thorax, Liver ECHO) as limited (LD) or extensive disease (ED) before and after MRI. MRI was positive in 12 BS negative (P = 0.003) and in 14 BMBA negative patients (P < 0.001), while in 8 patients, MRI was the only sign of ED, which resulted in a decrease of patients categorised with LD from 52 to 33%. However, in this small group of LD patients, there was no significant survival difference between LD (MRI pos) and LD (MRI neg) patients. It is concluded that MRI can be of value in the staging of LD patients, but it has no influence on survival.
在小细胞肺癌（SCLC）中，骨髓转移常通过骨闪烁显像（BS）和/或单侧骨髓活检及穿刺（BMBA）检测到。在本研究中，对42例SCLC患者胸椎和骨盆的磁共振成像（MRI）价值与BS及BMBA进行了比较，并评估了其临床意义。在MRI检查前后，患者根据BS、BMBA、胸部CT、肝脏超声检查进行分期，分为局限期（LD）或广泛期（ED）。MRI在12例BS检查阴性（P = 0.003）和14例BMBA检查阴性的患者中呈阳性（P < 0.001），而在8例患者中，MRI是ED的唯一征象，这使得被归类为LD的患者从52例减少到33例。然而，在这一小群LD患者中，LD（MRI阳性）和LD（MRI阴性）患者之间的生存差异无统计学意义。得出的结论是，MRI在LD患者分期中可能有价值，但对生存无影响。
