Maesawa C, Tamura G, Ogasawara S, Suzuki Y, Sakata K, Sugimura J, Nishizuka S, Sato N, Ishida K, Saito K, Satodate R
Department of Pathology, Iwate Medical University, Morioka, Japan.
Eur J Cancer. 1996 May;32A(5):896-8. doi: 10.1016/0959-8049(96)00010-x.
Tumour specimens from 111 patients with oesophageal squamous cell carcinoma were screened for loss of heterozygosity (LOH) at the deleted colorectal carcinoma (DCC) gene locus. DCC-LOH occurred in 10 of 61 informative cases (16%). No statistically significant correlation was observed between DCC-LOH and lymph node metastasis, histopathological grade or tumour stage. The survival of patients exhibiting DCC-LOH was not statistically different from that of patients without LOH. These results suggest that LOH at the DCC locus is not related to the acquisition of metastatic potential or the state of tumour cell differentiation in oesophageal squamous cell carcinoma.
对111例食管鳞状细胞癌患者的肿瘤标本进行检测，以筛查缺失型结直肠癌（DCC）基因位点的杂合性缺失（LOH）情况。在61例信息充分的病例中，有10例（16%）出现了DCC-LOH。未观察到DCC-LOH与淋巴结转移、组织病理学分级或肿瘤分期之间存在统计学上的显著相关性。出现DCC-LOH的患者生存率与未出现LOH的患者相比，在统计学上无差异。这些结果表明，食管鳞状细胞癌中DCC基因位点的LOH与转移潜能的获得或肿瘤细胞分化状态无关。
