三环类抗抑郁药对离体灌注豚鼠心脏的作用。

The effect of tricyclic antidepressant drugs on the isolated perfused guinea-pig heart.

Dumovic P, Trethewie E R, Burrows G D

Clin Exp Pharmacol Physiol. 1977 Jul-Aug;4(4):421-4. doi: 10.1111/j.1440-1681.1977.tb02679.x.

Abstract

The effects of tricyclic antidepressants were studied on the isolated perfused guinea-pig heart simultaneously recording myocardial contractile force and cardiac electrogram. 2. Tricyclic antidepressants in a concentration 4 X 10(-5) mol/1 decreased cardiac contractile force and increased cardiac conduction time. 3. Doxepin had significantly greater negative inotropic effect than nortriptyline, protriptyline, desipramine, amitriptyline and imipramine (P less than 0.01). 4. There was no significant difference in the increase in P-R interval (P less than 0.5) and QRS width (P greater than 0.95) between the tricyclic antidepressants. 5. The isolated perfused guinea-pig heart can be used as a toxicological model for testing and treating cardiac arrhythmias induced by tricyclic antidepressants.

摘要

研究了三环类抗抑郁药对离体灌注豚鼠心脏的作用，同时记录心肌收缩力和心电图。2. 浓度为4×10⁻⁵mol/1的三环类抗抑郁药可降低心脏收缩力并延长心脏传导时间。3. 多塞平的负性肌力作用明显大于去甲替林、普罗替林、地昔帕明、阿米替林和丙咪嗪（P＜0.01）。4. 三环类抗抑郁药之间在P-R间期延长（P＜0.5）和QRS波宽度增加（P＞0.95）方面无显著差异。5. 离体灌注豚鼠心脏可作为测试和治疗三环类抗抑郁药所致心律失常的毒理学模型。