Litvinova S V, Aristova V V, Shul'goskiĭ V V, Meshcheriakov A F, Kaliuzhnyĭ L V
Patol Fiziol Eksp Ter. 1996 Oct-Dec(4):39-41.
Rat experiments revealed a dose-dependent and naloxone-dependent analgetic effect of cocaine (0.5-3.0 mg/kg), evaluated by the tail-flick test. The cocaine-sensitive animals were morphine-sensitive and the cocaine-insensitive ones were morphine-insensitive. In some cocaine-insensitive rats, the use of cocaine led to that the first phase characterized by the lack of changes in nociception was followed by a hyperalgesic phase. It is suggested that cocaine produces an analgetic effect mainly via the delta-opioid mechanism.
大鼠实验显示，通过甩尾试验评估，可卡因（0.5 - 3.0毫克/千克）具有剂量依赖性和纳洛酮依赖性镇痛作用。对可卡因敏感的动物对吗啡也敏感，而对可卡因不敏感的动物对吗啡也不敏感。在一些对可卡因不敏感的大鼠中，使用可卡因导致以痛觉无变化为特征的第一阶段之后出现痛觉过敏阶段。提示可卡因主要通过δ-阿片类机制产生镇痛作用。
