Cuvelier A, Kuntz C, Sesboüé R, Muir J F, Martin J P
Unité INSERM 295, Faculté de Médecine de Rouen, Saint-Etienne du Rouvray.
Rev Mal Respir. 1997 Jan;14(1):1-10.
The matrix metalloproteinases (MMP) are a multigenic family involving 14 enzymes which can cleave most, if not all, the components of the extracellular matrix (interstitium and basement membranes). The present work reports on the main structural characteristics, the substrate preference and the site synthesis of these proteinases and their inhibitors (TIMP). Human MMPs are produced by various cell types and are involved in the remodelling of the extracellular matrix in many physiological and pathophysiological circumstances. Elastolytic MMPs produced by monocytes and/or macrophages (matrilysin, gelatinases, macrophage elastase) are likely to be implicated in the development of acquired pulmonary emphysema.
基质金属蛋白酶（MMP）是一个多基因家族，包含14种酶，这些酶能够切割细胞外基质（间质和基底膜）的大部分（即便不是全部）成分。本研究报告了这些蛋白酶及其抑制剂（TIMP）的主要结构特征、底物偏好和合成部位。人类MMP由多种细胞类型产生，并在许多生理和病理生理情况下参与细胞外基质的重塑。单核细胞和/或巨噬细胞产生的弹性蛋白酶MMP（基质溶素、明胶酶、巨噬细胞弹性蛋白酶）可能与获得性肺气肿的发展有关。
