Shapiro S D
Department of Medicine, Washington University Medical Center at Jewish Hospital, St. Louis, Missouri 63110.
Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 2):S160-4. doi: 10.1164/ajrccm/150.6_Pt_2.S160.
Mononuclear phagocytes have the capacity to produce an array of MMPs. Several of these proteinases are capable of degrading insoluble elastin, an important component for the structural stability of the lung. Matrilysin is a low molecular weight proteinase with a broad substrate specificity produced at highest levels in in vitro differentiated monocytes. The 92-kD gelatinase is a major product of human alveolar macrophages that is also an elastase. The most newly described member of the MMP family is human macrophage metalloelastase. This enzyme is also expressed in alveolar macrophages derived from cigarette smokers. Determining the contribution of these and other elastolytic proteinases to the pathogenesis of emphysema is a focus of ongoing research.
单核吞噬细胞有能力产生一系列基质金属蛋白酶。其中几种蛋白酶能够降解不溶性弹性蛋白，而弹性蛋白是肺结构稳定性的重要组成部分。基质溶素是一种低分子量蛋白酶，具有广泛的底物特异性，在体外分化的单核细胞中产生水平最高。92-kD明胶酶是人类肺泡巨噬细胞的主要产物，也是一种弹性蛋白酶。基质金属蛋白酶家族最新描述的成员是人类巨噬细胞金属弹性蛋白酶。这种酶也在来自吸烟者的肺泡巨噬细胞中表达。确定这些及其他弹性溶解蛋白酶在肺气肿发病机制中的作用是当前研究的一个重点。
