Gribkova N V, Eremin V F, Votiakov V I, Shchelkanov M Iu, Pashkova T A, Karamov E V
Zh Mikrobiol Epidemiol Immunobiol. 1996 Sep-Oct(5):27-9.
Cytokine-like antivirus factor, obtained from the culture fluid of chick embryo fibroblasts, was found to possess inhibitory activity with respect to HIV-1 (strains 1/Zmb and RF). The treatment of HIV-infected cell culture with cytokine-like factor was accompanied by a decrease in the cytopathic effect of the agent without manifestations of cytotoxicity. The combined use of the cytokine-like factor and azidothymidine at near-threshold concentrations was not accompanied by an increase in the antivirus effect, observed after the use of each preparation separately.
从鸡胚成纤维细胞培养液中获得的细胞因子样抗病毒因子，被发现对HIV-1（1/Zmb和RF株）具有抑制活性。用细胞因子样因子处理HIV感染的细胞培养物时，该因子的细胞病变效应降低，且无细胞毒性表现。细胞因子样因子与齐多夫定在接近阈值浓度下联合使用时，并未观察到比单独使用每种制剂时更强的抗病毒效果。
