Wang B, Li G, Fang J
Department of Otolaryngology, 2nd Clinic Medical College, China Medical University, Shenyang, P.R. China.
Acta Otolaryngol Suppl. 1996;523:105-7.
The immune function of tonsils and the immunological mechanisms of focal tonsillitis are still controversial. We do have some knowledge about the structure of tonsillar cells, but their functional status is still not clear. In 40 cases of chronic recurrent tonsillitis and 20 cases of focal tonsillitis with glomerular nephritis, cell culture of tonsillar lymphocytes was removed in vitro and 3H-tymidin incorporation applied to investigate the spontaneous DNA synthesis of tonsillar lymphocytes. The results demonstrated that: i) In chronic tonsillitis, spontaneous DNA synthesis of tonsillar lymphocytes in children is significantly stronger than that in adults (19,946 +/- 5,612 vs 9,216 +/- 5,702 cpm) (p <0.01). ii) Spontaneous DNA synthesis of tonsillar lymphocytes in focal tonsillitis is significantly stronger than that in the chronic recurrent tonsillitis in patients of the same age (25,307 +/- 12,231 cpm vs 12,455 +/- 7,914 cpm) (p <0.01). This indicates that the tonsillar lymphocytes are active in focal tonsillitis, can produce large amounts of memory B-cell clones, which reach other parts of the body through the blood and cause autoimmune reaction which can be blocked by tonsillectomy, thus curing the systemic disease.
扁桃体的免疫功能以及局灶性扁桃体炎的免疫机制仍存在争议。我们对扁桃体细胞的结构有所了解，但其功能状态仍不清楚。在40例慢性复发性扁桃体炎和20例伴有肾小球肾炎的局灶性扁桃体炎患者中，体外去除扁桃体淋巴细胞进行细胞培养，并应用3H-胸腺嘧啶核苷掺入法来研究扁桃体淋巴细胞的自发DNA合成。结果表明：i）在慢性扁桃体炎中，儿童扁桃体淋巴细胞的自发DNA合成明显强于成人（19,946±5,612对9,216±5,702 cpm）（p<0.01）。ii）在同年龄患者中，局灶性扁桃体炎患者扁桃体淋巴细胞的自发DNA合成明显强于慢性复发性扁桃体炎患者（25,307±12,231 cpm对12,455±7,914 cpm）（p<0.01）。这表明局灶性扁桃体炎中扁桃体淋巴细胞活跃，可产生大量记忆B细胞克隆，这些克隆通过血液到达身体其他部位并引发自身免疫反应，而扁桃体切除术可阻断这种反应，从而治愈全身性疾病。
