腺样体和扁桃体淋巴细胞中免疫球蛋白产生情况

Profile of immunoglobulin production in adenoid and tonsil lymphocytes.

作者信息

Hata M, Asakura K, Saito H, Morimoto K, Kataura A

机构信息

Department of Otolaryngology, Sapporo Medical University, School of Medicine, Japan.

出版信息

Acta Otolaryngol Suppl. 1996;523:84-6.

PMID:9082819

Abstract

The adenoids and tonsils are thought to be essential parts of the system protecting against pathogens invading the upper respiratory tracts. We have examined IgA-spot forming cells (SFC) as well as IgG- and IgM-SFC in human adenoid and tonsil lymphocytes. The majority of SPC were revealed to be IgG type in adenoid and tonsil lymphocytes. However, when the changes in the number of SFC were examined following 6 days of incubation in the presence of LPS and Con A, an increase in IgA-SFC was noted in both adenoid and tonsillar lymphocytes, suggesting that adenoid and tonsillar lymphocytes differentiate into IgA forming cells under appropriate conditions.

摘要

腺样体和扁桃体被认为是抵御病原体侵入上呼吸道系统的重要组成部分。我们检测了人腺样体和扁桃体淋巴细胞中的IgA斑点形成细胞（SFC）以及IgG和IgM-SFC。结果显示，腺样体和扁桃体淋巴细胞中的大多数SPC为IgG型。然而，当在LPS和Con A存在的情况下孵育6天后检测SFC数量的变化时，发现腺样体和扁桃体淋巴细胞中的IgA-SFC均增加，这表明腺样体和扁桃体淋巴细胞在适当条件下可分化为IgA形成细胞。