人类摄入砷后砷的化学形态变化。
Changes in the chemical speciation of arsenic following ingestion by man.
作者信息
Crecelius E A
出版信息
Environ Health Perspect. 1977 Aug;19:147-50. doi: 10.1289/ehp.7719147.
The concentrations of four chemical species of arsenic in urine were observed with time, after ingestion of three different chemical species of arsenic. The arsenic-rich substances ingested, including arsenite-rich wine, arsenate-rich drinking water, and crab meat which contained organo-arsenic compounds. After ingestion of arsenite-rich wine, approximately 10% of the arsenic was excreted as arsenite, but the majority of the arsenic was methylated to methylarsonic acid and dimethylarsinic acid and excreted. After ingestion of arsenate-rich water, elevated levels of both arsenate and dimethylarsinic acid were observed. When crab meat was ingested, none of these four arsenic species were observed at elevated levels until the urine was heated in 2N NaOH. After the hot base digestion, high levels of dimethylarsinic acid were detected in these samples. The apparent biological half-lives were on the order of 10 hr for inorganic arsenic and 30 hr for the methylated arsenic forms.
摄入三种不同化学形态的砷后，随时间观察了尿液中四种砷化学形态的浓度。所摄入的富砷物质包括富亚砷酸盐的葡萄酒、富砷酸盐的饮用水以及含有有机砷化合物的蟹肉。摄入富亚砷酸盐的葡萄酒后，约10%的砷以亚砷酸盐形式排出，但大部分砷被甲基化为甲基胂酸和二甲基胂酸并排出。摄入富砷酸盐的水后，观察到砷酸盐和二甲基胂酸的水平均升高。摄入蟹肉后，在尿液用2N氢氧化钠加热之前，未观察到这四种砷形态中的任何一种水平升高。热碱消化后，在这些样品中检测到高浓度的二甲基胂酸。无机砷的表观生物半衰期约为10小时，甲基化砷形态的表观生物半衰期约为30小时。
Zotero 插件