Ohbu M, Saegusa M, Kobayashi N, Tsukamoto H, Mieno H, Kakita A, Okayasu I
Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan.
Cancer. 1997 Apr 1;79(7):1287-93. doi: 10.1002/(sici)1097-0142(19970401)79:7<1287::aid-cncr3>3.0.co;2-e.
Recent studies on the role of bcl-2 in malignant tumors have suggested its prognostic significance. The goals of the current study were to determine any correlation between bcl-2 expression in esophageal squamous cell carcinoma and histopathology, lymph node metastasis, and clinical variables, and to assess its applicability as a parameter for prognosis.
Immunohistochemical staining for bcl-2 (clone 124) was performed on archival material from 105 esophageal squamous cell carcinomas. The results were compared among patient subgroups.
bcl-2 was expressed in 58% of esophageal carcinomas, demonstrating positive correlations with a lack of keratinization and an early stage of disease. Lymph node metastasis was significantly less frequently observed in the subset of early stage carcinomas with bcl-2 staining. Univariate analysis revealed significantly longer disease free survival in patients with bcl-2 positive carcinomas than in those bcl-2 negative. bcl-2 expression did not have independent prognostic value in a multivariate survival analysis.
bcl-2 is frequently expressed in esophageal carcinomas, and this expression is positively associated with nonkeratinization and an early stage, whereas it is negatively linked with lymph node metastasis and may indicate a favorable prognosis.
近期有关bcl-2在恶性肿瘤中作用的研究提示了其预后意义。本研究的目的是确定食管鳞状细胞癌中bcl-2表达与组织病理学、淋巴结转移及临床变量之间的相关性，并评估其作为预后参数的适用性。
对105例食管鳞状细胞癌存档材料进行bcl-2（克隆号124）免疫组化染色。在不同患者亚组间比较结果。
58%的食管癌中表达bcl-2，显示与无角化及疾病早期呈正相关。在bcl-2染色的早期癌亚组中，淋巴结转移的观察频率显著较低。单因素分析显示，bcl-2阳性癌患者的无病生存期明显长于bcl-2阴性患者。在多因素生存分析中，bcl-2表达无独立预后价值。
bcl-2在食管癌中常表达，且这种表达与无角化及早期呈正相关，而与淋巴结转移呈负相关，可能提示预后良好。
