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Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site.

作者信息

Tucker T J, Lumma W C, Mulichak A M, Chen Z, Naylor-Olsen A M, Lewis S D, Lucas R, Freidinger R M, Kuo L C

机构信息

Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.

出版信息

J Med Chem. 1997 Mar 14;40(6):830-2. doi: 10.1021/jm960762y.

DOI:10.1021/jm960762y
PMID:9083470
Abstract
摘要

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