Petter C
Experientia. 1977 Oct 15;33(10):1384-6. doi: 10.1007/BF01920195.
Mouse foetuses were treated by Thalidomide on days 11-12 in order to verify whether the drug would induce blood abnormalities leading to circulatory troubles. About 18% of the treated foetuses showed both severe limb haemorrhages on day 14, and obvious alterations of the nucleated red blood cells of vitelline origin. These blood abnormalities, occurring suddenly during the well-known 'critical stage' of foetal development, could be responsible for circulatory blocks leading to necrosis.
为了验证沙利度胺是否会诱发导致循环系统问题的血液异常，在第11至12天对小鼠胎儿进行了该药物处理。约18%接受处理的胎儿在第14天出现了严重的肢体出血，以及明显的卵黄囊来源有核红细胞改变。这些血液异常在胎儿发育的著名“关键阶段”突然出现，可能导致循环阻滞进而引发坏死。
