Zhang H Y, Ishigaki T, Tani K, Chen K, Shih J C, Miyasato K, Ohara K, Ohara K
Department of Psychiatry, Hamamatsu University School of Medicine, Shizuoka, Japan.
Biol Psychiatry. 1997 Apr 1;41(7):768-73. doi: 10.1016/S0006-3223(96)00160-6.
Genes that regulate the serotonin (5-HT) system including 5-HT receptors may be involved in mood disorders. We studied 5-HT2A receptor exons and the adjacent intron regions in 102 patients with mood disorders (71 depressive disorders and 31 bipolar disorders). In 34 mood disorder cases, the gene encoding the 5-HT1A receptor had been sequenced, but no disease-specific polymorphism was found. The substitution of C for T at position 102 in exon 1, which had been reported by Warren et al., was confirmed. The corresponding amino acid, serine, did not change. The allele frequency of C [corrected] at position 102 was significantly higher in patients with depressive disorders than in those with bipolar disorders and healthy control subjects. Furthermore, the mean age of onset in the patients heterozyous for the T and C alleles was lower than that in those homozygous for the C allele. No other polymorphism in the gene was found.
包括5-羟色胺（5-HT）受体在内的调节5-羟色胺系统的基因可能与情绪障碍有关。我们研究了102例情绪障碍患者（71例抑郁症和31例双相情感障碍）的5-HT2A受体外显子及相邻内含子区域。在34例情绪障碍病例中，对编码5-HT1A受体的基因进行了测序，但未发现疾病特异性多态性。Warren等人报道的第1外显子第102位由T替换为C的情况得到了证实。相应的氨基酸丝氨酸未发生改变。抑郁症患者第102位C[校正后]的等位基因频率显著高于双相情感障碍患者和健康对照者。此外，T和C等位基因杂合的患者的平均发病年龄低于C等位基因纯合的患者。该基因未发现其他多态性。
