Wojczys R, Bednarz W
1st Department of Surgery, University of Medicine, Wrocław, Poland.
Eur J Surg. 1997 Mar;163(3):215-7.
To evaluate the healing of single-layer end-to-end colonic anastomoses in rats in which the inferior mesenteric artery had been ligated.
Controlled experiment.
Medical school, Poland.
20, 2-month-old inbred Buffalo rats (n = 10 in each group).
Laparotomy with ligation of the inferior mesenteric artery (laparotomy alone in the control group), followed by segmental colonic resection and primary anastomosis 24 hours later, and resection of the anastomosis 4 days later.
Degree of contamination and inflammation of peritoneal cavity and histological evaluation of the anastomosis.
No animal died and no anastomosis leaked. There were no histological differences in the extent of early healing between the groups. In 2 animals in the experimental group pathogens were grown from the peritoneal culture (Escherichia coli and Bacteroides fragilis in each case).
High ligation of the inferior mesenteric artery had no deleterious effect on the healing of colonic anastomoses in rats.
