Nolan P E
Department of Pharmacy Practice and Science, College of Pharmacy, University of Arizona, Tucson 85721-0207, USA.
Pharmacotherapy. 1997 Mar-Apr;17(2 Pt 2):65S-75S; discussion 89S-91S.
Although no antiarrhythmic agent has ideal pharmacokinetic and pharmacodynamic characteristics, it is useful to evaluate antiarrhythmic agents in terms this ideal profile. The most desirable characteristics of an intravenous antiarrhythmic agent for treating ventricular arrhythmias are outlined. The basic pharmacokinetic and pharmacodynamic properties of the most commonly used agents for this indication-including amiodarone, bretylium, lidocaine, procainamide, and quinidine-are also reviewed, in light of this profile.
尽管没有一种抗心律失常药物具有理想的药代动力学和药效学特性，但根据这一理想特性来评估抗心律失常药物是有用的。本文概述了用于治疗室性心律失常的静脉注射抗心律失常药物最理想的特性。鉴于此特性，还回顾了用于该适应症的最常用药物（包括胺碘酮、溴苄铵、利多卡因、普鲁卡因胺和奎尼丁）的基本药代动力学和药效学特性。
