Mojzis J, Pomfy M, Kohút A, Benes L, Nicák A, Mirossay L
Department of Pharmacology, Medical Faculty, Safarik University, Kosice, Slovak Republic.
Physiol Res. 1996;45(5):399-403.
The ability of stobadine to prevent gastric mucosal injury was tested in rat gastric ischaemia induced by 30 min clamping of the coeliac artery with subsequent 30 min reperfusion. Serious injury of gastric mucosa (macroscopic and microscopic) and the increase of microvascular permeability was found after ischaemia/reperfusion in rats without stobadine. After oral pretreatment with stobadine (5 mg.kg-1, 30 min before surgery), the development of gastric mucosal lesions and changes of vascular permeability were significantly decreased.
在通过夹闭腹腔动脉30分钟随后再灌注30分钟诱导的大鼠胃缺血模型中，测试了司他定预防胃黏膜损伤的能力。在未使用司他定的大鼠缺血/再灌注后，发现胃黏膜出现严重损伤（宏观和微观）以及微血管通透性增加。在术前30分钟口服司他定（5mg·kg-1）进行预处理后，胃黏膜损伤的发展和血管通透性的变化显著降低。
