Silva R H, Bellot R G, Vital M A, Frussa-Filho R
Departmento de Farmacologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil.
Psychopharmacology (Berl). 1997 Feb;129(4):322-8.
The beneficial effects of monosialoganglioside GM1 (GM1) on learning and memory have been detected mostly in animals presenting genetic, lesion-induced or age-related memory deficits. The present study was carried out to investigate the effects of GM1 on the discriminative avoidance behavior of normal adult mice. EPM-M1 male mice were treated daily IP with 50 mg/kg GM1 or saline for 14 days. The discriminative avoidance conditioning was performed on day 15 in a modified elevated plus-maze. In one of the enclosed arms, the animals received aversive stimulation (light and noise). Tests were performed on days 20, 25 and 30 (tests 1, 2 and 3). The time the animals spent in each of the enclosed arms was recorded. In tests 1 and 2, GM1-treated mice spent less time in the aversive arm in comparison to the non-aversive enclosed arm. On the other hand, control animals spent a shorter time in a aversive arm only in test 1. The results suggest that the beneficial effects of GM1 on learning and memory can be observed in normal animals as well.
单唾液酸神经节苷脂GM1（GM1）对学习和记忆的有益作用大多在呈现基因、损伤诱导或年龄相关记忆缺陷的动物中被检测到。本研究旨在探讨GM1对正常成年小鼠辨别性回避行为的影响。将EPM-M1雄性小鼠每天腹腔注射50mg/kg GM1或生理盐水，持续14天。在第15天，在改良的高架十字迷宫中进行辨别性回避条件训练。在其中一个封闭臂中，动物接受厌恶刺激（光和噪音）。在第20、25和30天进行测试（测试1、2和3）。记录动物在每个封闭臂中花费的时间。在测试1和2中，与无厌恶刺激的封闭臂相比，接受GM1治疗的小鼠在厌恶臂中花费的时间更少。另一方面，对照动物仅在测试1中在厌恶臂中花费较短时间。结果表明，GM1对学习和记忆的有益作用在正常动物中也可以观察到。
