Gilbert D G, Estes S L, Welser R
Department of Psychology, Southern Illinois University, Carbondale 62901, USA.
Psychopharmacology (Berl). 1997 Feb;129(4):382-9. doi: 10.1007/s002130050204.
Effects of smoking multiple cigarettes on EEG, vigilance, and subjective state were assessed in a repeated measures design where noise level (high versus minimal) was crossed with nicotine dose (quasi-ad lib own versus 1.0 mg FTC nicotine machine-delivered dose versus 0.05 mg FTC nicotine machine-delivered dose). Vigilance was increased by nicotine, but not by noise and there was no noise by dose interaction. Effects of nicotine on EEG varied as a function of dose, noise, hemisphere, time, and eyes-open versus eyes-closed condition. Smoking normal nicotine delivery (0.9-1.1 mg FTC-estimated) cigarettes resulted in decreases in percentages of delta and theta EEG magnitude and increased percentage beta-1 EEG magnitude across conditions and time. Changes in alpha and theta magnitude were dependent on eyes being open versus closed. Hemispheric asymmetries varied as a function of noise and time. Consistent with inverted "U" models, effects of nicotine on EEG were clearly stimulant during the quiet conditions while there were minimal to no differences between nicotine doses during the high-noise conditions. The failure of nicotine to modify mood is interpreted in terms of bioinformational models of nicotine's subjective effects.
在一项重复测量设计中，评估了吸多支香烟对脑电图（EEG）、警觉性和主观状态的影响，其中噪声水平（高与低）与尼古丁剂量（准随意自用与1.0毫克联邦贸易委员会（FTC）尼古丁机器输送剂量与0.05毫克FTC尼古丁机器输送剂量）交叉。尼古丁可提高警觉性，但噪声不能，且不存在噪声与剂量的交互作用。尼古丁对EEG的影响随剂量、噪声、半球、时间以及睁眼与闭眼状态而变化。吸正常尼古丁输送量（估计为0.9 - 1.1毫克FTC）的香烟会导致在各种条件和时间下，δ波和θ波EEG幅度百分比降低，β-1波EEG幅度百分比增加。α波和θ波幅度的变化取决于眼睛是睁开还是闭合。半球不对称性随噪声和时间而变化。与倒“U”模型一致，在安静条件下尼古丁对EEG的影响明显具有刺激性，而在高噪声条件下尼古丁剂量之间的差异极小或无差异。尼古丁未能改变情绪可根据尼古丁主观效应的生物信息模型来解释。
