Nomura A
Nihon Yakurigaku Zasshi. 1977 May;73(4):423-35. doi: 10.1254/fpj.73.423.
Sulfhemoglobin (SHb) and methemoglobin (MHb) formations by various aniline erivatives were examined by a single and three consecutive intraperitoneal administrations to mice. It was found that with a single administraion, methemoglobinemia was induced by aniline, 2-methylaniline, 3-methylaniline, 4-methylaniline, 3-trifluoromethylaniline (3-TFMA), 4-trifluoromethylaniline (4-TFMA), 2, 3-dichloroaniline, 2-aminopehnol, acetanilide (AA), 2-hydroxyacetanilide, N-methylaniline (NMA), N,N-dimethylaniline (NDMA), N-ethylaniline (NEA) and N,N-diethylaniline, and was not observed with 2, 3-dimethylanilnie, 2-trifluoromethylaniline, 3-aminophenol, 4-aminophenol, 2. 6-dichloroaniline, 3-hydroxyacetanilide (3-HAA), 4-hydroxyacetanilide (4-HAA), 2-aminobenzoic acid, 3-aminobenzoic acid, 4-aminobenzoic acid and 4-chloro-2-aminobenzoic acid. On the other hand, sulfhemoglobinemia which appeared much more delayed than MHb, with a single administration, was found to be induced by 3-TFMA, 4-TFMA and NMA. Furthermore, with three consecutive administrations, such was induced by AA, 3-HAA, NDMA and NEA even though SHb was not demonstrated with a single administration. Structure-SHb and MHb forming property relationships were discussed.
通过对小鼠进行单次和连续三次腹腔注射，研究了各种苯胺衍生物形成硫化血红蛋白（SHb）和高铁血红蛋白（MHb）的情况。结果发现，单次注射时，苯胺、2-甲基苯胺、3-甲基苯胺、4-甲基苯胺、3-三氟甲基苯胺（3-TFMA）、4-三氟甲基苯胺（4-TFMA）、2,3-二氯苯胺、2-氨基酚、乙酰苯胺（AA）、2-羟基乙酰苯胺、N-甲基苯胺（NMA）、N,N-二甲基苯胺（NDMA）、N-乙基苯胺（NEA）和N,N-二乙苯胺可诱导高铁血红蛋白血症，而2,3-二甲基苯胺、2-三氟甲基苯胺、3-氨基酚、4-氨基酚、2,6-二氯苯胺、3-羟基乙酰苯胺（3-HAA）、4-羟基乙酰苯胺（4-HAA）、2-氨基苯甲酸、3-氨基苯甲酸、4-氨基苯甲酸和4-氯-2-氨基苯甲酸则未观察到这种情况。另一方面，单次注射时出现的比MHb延迟得多的硫化血红蛋白血症被发现是由3-TFMA、4-TFMA和NMA诱导的。此外，连续三次注射时，AA、3-HAA、NDMA和NEA即使单次注射未显示出SHb也可诱导这种情况。讨论了结构与SHb和MHb形成特性的关系。
