Nomura A
Nihon Yakurigaku Zasshi. 1977 Oct;73(7):793-802. doi: 10.1254/fpj.73.793.
Sulfhemoglobin (SHb) and methemoglobin (MHb) formations by various compounds were examined by single and three consecutive intraperitoneal administrations to mice. With a single administration, methemoglobinemia was induced by diphenylamine (DPA), 1-naphthylamine (NA), phenylnaphthylamine (PNA), N-(1-naphthyl) anthranilic acid (N1) and N-(1'-naphthyl)-2-aminophenylacetic acid (IG240), and was not observed with phenylanthranilic acid (PAA), N-benzoyl-N'-phenyl-2, 6-diaminobenzoic acid (BPAA), flufenamic acid (FA), mefenamic acid (MFA), N-(2-6-dichlorophenyl) anthranilic acid (CPAA), N-(2', 6'-dichlorophenyl)-2-aminophenylacetic acid (CPPA), nine derivatives of N1 and two derivatives of IG240. On the other hand, sulfhemoglobinemia, with a single administration, was found to be induced by NA. Furthermore, with three consecutive administrations, such was induced by DPA, PAA, BPAA and FA even though SHb was not demonstrated with a single administration, and was not observed with MF, CPAA, CPPA and various derivatives of N1 and IG240.
通过对小鼠进行单次和连续三次腹腔注射，研究了各种化合物导致硫血红蛋白（SHb）和高铁血红蛋白（MHb）形成的情况。单次注射时，二苯胺（DPA）、1-萘胺（NA）、苯基萘胺（PNA）、N-（1-萘基）邻氨基苯甲酸（N1）和N-（1'-萘基）-2-氨基苯乙酸（IG240）可诱导高铁血红蛋白血症，而苯基邻氨基苯甲酸（PAA）、N-苯甲酰基-N'-苯基-2,6-二氨基苯甲酸（BPAA）、氟芬那酸（FA）、甲芬那酸（MFA）、N-（2,6-二氯苯基）邻氨基苯甲酸（CPAA）、N-（2',6'-二氯苯基）-2-氨基苯乙酸（CPPA）、N1的九种衍生物和IG240的两种衍生物则未观察到这种情况。另一方面，单次注射时，NA可诱导硫血红蛋白血症。此外，连续三次注射时，尽管单次注射未显示出SHb，但DPA、PAA、BPAA和FA可诱导硫血红蛋白血症，而MF、CPAA、CPPA以及N1和IG240的各种衍生物则未观察到这种情况。
